Here's my mousepad and mouse next to my crappy laptop that I use. As you can see, it rests on a glass table in my living room where I usually hang out. My arm is always up and not resting on anything, my mouse is wireless Logitec M510, and the pad is covered in murderous puppies. There are flat-surfaced, reflective gaming pads you can buy that stick to the surface that are quite good.
As far as one shot kills...I get them, especially after a few 'adult-beverages', as my aim and mouse-button trigger squeeze is smoother...and after a few kills using the rubber bullets afterwhich I finally get the good ammo. Lag can play a part, especially in my case where the computer isn't high end. I don't use really fast scroll for mouse as I overshoot targets if it's too quick, but it's set fast enough to react in close combat.
Are you aiming for the enemy's head? If not, you should, as the damage is best for one shot/one kill.
Here's a pic of my mouse:
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